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Arrayit InnoScan® 910, 910AL and 1100AL High Speed Fluorescence Microarray Scanners
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Arrayit InnoScan® 910, 910AL and 1100AL high-performance microarray scanners comprise the newest instruments in our laser scanning series. These compact, desktop instruments feature proprietary rotary motion control for superior speed and durability, complete controller and Mapix® quantification and data analysis software, dynamic auto-focusing for superior precision, and two-color (910 and 910AL) and three-color (1100AL) detection. The 1100AL is our top-of-the-line scanner featuring 488 nm (FITC), 532 nm (cyanine 3) and 635 nm (cyanine 5) three-color scanning and a world’s best 0.5 µm scan resolution for microarray and tissue microarray applications in research and clinical laboratories leveraging genomics, proteomics, diagnostics and pharmaceutical drug discovery.
Figure 1. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners are ideal for low- and medium-density two-color DNA microarrays for comparative gene expression analysis of test and control samples. Two-color microarrays offer the market’s most rapid and affordable means of identifying genes involved in human disease onset and progression, drug mode of action and many other pathways.
Figure 2. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners support a wide variety of 1 x 25 x 76 mm glass substrate slides including silane-activated glass, nitrocellulose-coated glass and slides with other membranes, SuperMask and other microarray dividers, and popular formats from major suppliers including Arrayit, Agilent and Schott.
Figure 3. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners support the growing protein microarray industry including antigen, antibody, peptide, and reverse phase cell lysate microarrays for protein expression assays, protein binding studies, drug discovery, serum-based immunoassays and many others.
Figure 4. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners empower high-density DNA and protein microarray analysis including chips with hundreds of thousands to millions of individual features. The 910 and 910AL and the 1100AL instruments utilize 1.0 µm and 0.5 µm scan resolution, respectively, to rapidly interrogate the human genome and proteome in a highly accurate and cost-effective manner.
Figure 5. Arrayit InnoScan 910 and 910AL high-speed microarray scanners offer two-color 532 nm and 635 nm detection, 1 µm scan resolution and single substrate slide (910) and 24-slide autoloader (910AL) for exceptional performance and ease-of-use in compact desktop scanners. All systems are equipped with a BioBlue Personal Computer, Mapix® quantification and analysis software, and complete cables and accessories for 30-minute setup time and years of reliable performance.
Table 1. Arrayit InnoScan® 910, 910AL and 1100AL Microarray Scanner Specifications.
Specification |
Arrayit InnoScan® 910 and 910AL |
Arrayit InnoScan® 1100AL |
General Description |
Characterized by simplicity of use, competitive price and superior image quality, Arrayit® InnoScan® 910 scanners are ideal instruments for scanning most high density microarrays available on the market. The single substrate slide (910) and 24-substrate slide autoloader (910AL) scanners feature high resolution 1 µm scanning, high speed 3.5 min per slide 10 µm scan time, reliable and traceable results with barcode reading, comprehensive Mapix image quantification and analysis software, and proprietary high-speed Arrayit BioBlue Computing to manage the 5.74 GB data files produced by 1 µm scanning. |
Characterized by ease of use, performance and versatility, the Arrayit InnoScan 1100AL is an ideal instrument for high density DNA, protein, tissue and whole cell microarrays and one-, two- and three-color applications. The 24-substrate slide autoloader 1100AL features a market-leading 0.5 µm scan resolution equivalent to a 20x optical objective, high speed 3.5 min per slide 10 µm scan time, reliable and traceable results with barcode reading, real-time auto-focusing, confocal PMT detection, user-friendly Mapix image acquisition and analysis software, and proprietary high-speed Arrayit BioBlue Computing to manage the 22.96 GB data files produced by 0.5 µm scanning. |
Applications |
Arrayit InnoScan 910 and 910AL instruments are ideal for scanning most low-, medium- and high-density microarrays currently available on the market for genotyping, gene expression comparative genomic hybridization (CGH), copy number variation (CNV), DNA methylation, miRNA studies, carbohydrate microarrays, antigen and antibodiy microarrays, proteomics and many other appolications. |
The Arrayit InnoScan 1100AL instrument is ideal for rapid and high-performance automated scanning of low-, medium- and high-density microarrays containing DNA, peptides, antibodies, microenvironment sensors, transfected cells, glycans and many other sample types for genotyping, gene expression, comparative genomic hybridization (CGH), copy number variation (CNV), DNA methylation, miRNA studies, biomarker identification, human diseaes analysis, tissue microarray (TMA), tissue immunofluorescence for one-, two- and three-color applications in research, life sciences, diagnostics, pharmaceuticals and other areas. |
Technology |
Arrayit InnoScan® 910 and 910AL instruments leverage confocal scanning, two lasers, two extremely sensitive analog photomultiplier tubes (PMT), and linear gain from 0.1-100%. Full PMT control makes it easy to adjust scanner sensitivity to read the complete range of microarray signal intensities. Real-time auto-focusing ensures scan uniformity across the entire substrate slide. Extended Dynamic Range (XDR) and 20-bit TIFF images enable dynamic range exceeding 1 x 10^6 and detection of the dimmest signals while avoiding saturation. The 910 and 910AL have excellent photometric properties, particularly in terms of sensitivity and signal-to-noise ratio. |
The Arrayit InnoScan® 1100AL instrument leverages confocal scanning, three lasers, three extremely sensitive analog photomultiplier tubes (PMT), and linear gain from 1-100%. Full PMT control makes it easy to adjust scanner sensitivity to read the complete range of microarray signal intensities. Real-time auto-focusing ensures scan uniformity across the entire substrate slide. Extended Dynamic Range (XDR) and 20-bit TIFF images enable dynamic range exceeding 1 x 10^6 and detection of the dimmest signals while avoiding saturation. The 1100AL has excellent photometric properties, particularly in terms of sensitivity and signal-to-noise ratio. |
Resolution |
1-40 µm per pixel |
0.5-40 µm per pixel |
Excitation wavelength |
532 nm and 635 nm |
488 nm, 532 nm and 635nm |
Compatible fluorophores |
532 nm: Cy3, Alexa 546, Alexa 555 |
488 nm: Cy2, Alexa488, FITC |
Microarray format |
Standard glass substrate slide format 1 x 25 x 76 mm |
Standard glass substrate slide format 1 x 25 x 76 mm |
Maximal scan area |
22 x 74 mm |
22 x 74 mm |
Focus |
Automatic or manual |
Automatic or manual |
Detection |
Analog PMT and true confocal detection |
Analog PMT and true confocal detection |
PMT gain |
Linear from 0.1 to 100% |
Linear from 1 to 100% |
Scanning mode |
Simultaneous or sequential |
Simultaneous or sequential |
Scanning speed |
10 to 35 lines per second |
10 to 35 lines per second |
Scanning time |
3.5 minutes to scan a whole slide at 10 µm per pixel resolution |
3.5 minutes to scan a whole slide at 10 µm per pixel and 3 colors |
Dimensions |
32 x 55 x 43 cm (12.6” x 21.7” x 16.9” for the 910 |
33 x 66 x 44 cm3 (13” x 26” x 17.3”) for the 1100AL |
Weight |
28 Kg (62 lbs) for the 910 |
39 Kg (85.8 lbs) for the 1100AL |
Interface |
Ethernet |
Ethernet |
Barcode scanner |
Yes |
Yes |
Image analysis and processing software |
Mapix® |
Mapix® |
Image file format |
16-bit and 20-bit TIFF |
16-bit and 20-bit TIFF |
Autoloader |
24-slide automated (910AL) |
24-slide automated |
Figure 6. Arrayit InnoScan 910, 910AL and 1100AL Microarray Scanners feature compact benchtop designs to permit user-friendly operation in a wide range of laboratory environments including research facilities and class 1 cleanroom manufacturing and testing centers.
Figure 7. Arrayit InnoScan 1100AL Microarray Scanner data image for a high density peptide microarray containing 10 µm feature size, 16 µm spacing and 440,000 peptide features per square centimeter. Data courtesy Dr. Alexander Nesterov-Muller, Institute of Microstructure Technology (IMT), Eggenstein-Leopoldshafen, Germany.
