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Services - Splice Chips Splice Variant Microarrays Gilbert, W., Science, 1998. 282: p. 659-661. Consortium, I., Initial sequencing and analysis of human genome. Nature, 2001. 409(6822): p. 860-921. Kan Z, R.E., Gish WR, States DJ., Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res., 2001. 11(5): p. 889-900. Johnson JM, C.J., Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD., Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science, 2003. 302(5653): p. 2141-2144. Graveley, B., Alternative splicing: increasing diversity in the proteomic world. Trends Genet., 2001. 17(2): p. 100-107. Maniatis T, T.B., Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature, 2002. 418(6894): p. 236-243. Modrek B, L.C., Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nat Genet., 2003. 34(2): p. 177-180. Garciaa-Blanco, M.A., A.P. Baraniak, and E.L. Lasda, Alternate splicing in disease and therapy. Nature Biotechnology, 2004. 22(5): p. 535-546. Bracco, L. and J. Kearsey, The relevance of alternate splicing to pharacogenomics. Trends in Biotechnology, 2003. 21: p. 346-353. Murphy MP, B.M., Clark LS, Cayouette M, Benson L, Morris DM, Polli JW., Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial. Pharmacogenetics., 2000. 10(7): p. 583-590. Stenson PD, B.E., Mort M, Phillips AD, Shiel JA, Thomas NS, Abeysinghe S, Krawczak M, Cooper DN., Human Gene Mutation Database (HGMD): 2003 update. Hum Mutat., 2003. 21(6): p. 577-581. Hanioka N, K.S., Meyer UA, Gonzalez FJ., The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site. Am J Hum Genet., 1990. 47(6): p. 994-1001. Xu Q, L.C., Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences. Nucleic Acids Res. 2003 Oct 1;31(19):5635-43., 2003. 31(19): p. 5635-5643.
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