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Arrayit Corporation (ARYC) leads and empowers the genetic, research, pharmaceutical, and diagnostic communities through the discovery, development and manufacture of proprietary life science technologies and consumables for disease prevention, treatment and cure.  - Powerful Science for Life™

Investors - Arrayit Newsletter Archive

Arrayit Corporation (ARYC) provides company newsletter to ARYC investors, prospective investors, analysts, customers and the public. Click here to subscribe to the Arrayit newsletter and browse the newsletter archive for a list of recent newsletter communications.

June 6, 2013
The-First-Array
"Ron Davis and I were studying plant transcription factors in 1990, but progress was slow and arduous because the gene expression tools were so primitive. We conceived of the DNA microarray in 1993 to speed up gene expression analysis by combining biology and high technology. We adapted Affymetrix VLSIPS technology to synthesize yeast microarrays, and measured gene expression in yeast cells by hybridizing fluorescent probes derived from mRNA. The image shows the very first microarray experiment, with colored locations on the microarray providing readouts of expressed yeast genes. We worked frantically to improve the technology, and generated the first quantitative DNA microarray data using robotically printed plant cDNAs amplified by PCR. Science magazine kindly published our work (M. Schena et al., "Quantitative monitoring of gene expression patterns with a complementary DNA microarray." Science, 270:467-70, 1995), and since then the technology has exploded."

- Mark Schena, August 25, 2003 (original data and text featured on p. 2 of the Arrayit 2013-2014 catalog)

Click here for Arrayit microarray products and services.

June 6, 2013
Arrayit-2013-2014-catalog
Arrayit empowers researchers and clinicians with versatile, affordable, high-performance microarray products and services. Building on company president Dr. Mark Schena's foundational scientific work (Schena et al., Science 270, 467-470, 1995), Arrayit microarray technology has a 15-year success record in the marketplace and 4,000 installations worldwide. Gene expression, genotyping, protein expression profiling, tissue microarrays, diagnostics, and many other applications are enabled with glass substrate slides on a universal microarray platform.

Click here for our 2013-2014 catalogs.

May 7, 2013
ozone-free-box
Arrayit offers the market's finest and most affordable ozone-free enclosures for microarray experimentation based on ozone-sensitive fluorescent dyes including Cy3, Cy5 and other fluors. Ozone-free boxes utilize catalytic converters and HEPA filtration to create ozone- and particle-free work environments ideal for microarray printers, scanners and processing equipment that benefit from 5 parts-per-billion (5 ppb) ozone compared to 10-100X higher ambient levels. A central sliding door protected by an ozone-free air curtain across the front of the enclosure permits accessibility during operation. Available in several different configurations and optimized for Arrayit, Agilent, Affymetrix, and Illumina instruments.

Click here for Ozone-Free Enclosures.

April 8, 2013
1000-genome
Arrayit offers a credible $1,000 genome with H25K Whole Human Genome Chips containing gene-specific capture elements for every gene in the human genome and extensive controls to allow detailed genomic analysis for less than $1K per sample. H25K reports to >250,000 cellular mRNAs, empowering researchers and clinicians to "deep dive" the human genome with unprecendented sensitivity for human disease markers, drug targets, activated and repressed cellular pathways and many other human biology applications with no minimum purchases and a total labor time of less than 8 hours. H25K is configured in the standard glass substrate slide format (25 x 76 mm) for compatibility with >10,000 microarray scanners and extensive commercial products from Arrayit, Agilent, Molecular Devices and other vendors. H25K functional genomic analysis ensures biologically relevant results for studies in cancer, neurodegeneration, stem cell and synthetic biology, epigenomics and immunology.

Click here for the Arrayit $1,000 Genome.

March 20, 2013
SpotBot-Extreme

Arrayit SpotBot® Extreme (SBX) Microarrayers empower researchers to manufacture all types of microarrays with speed, precision and affordability. Arrayit's patented contact printing technology loads and delivers diverse samples types including cDNAs, oligonucleotides, PNAs, peptides, peptoids, proteins, antibodies, antigens, phage preparations, carbohydrates, small molecules and many others. SBX instruments offer 16 microarray printing pins and 28 substrate slides for an excellent balance of throughput and cost management, with megasonic pin cleaning and humidity control as standard features. SBX Protein Edition systems include instrument cooling from ambient to 4°C for the most demanding proteomic applications. Arrayit SpotBot® Extreme packages, complete with a personal computer, LED screen, keyboard, mouse, mouse pad and all cables for a user-friendly 60-minute setup time, arrive pre-calibrated and ready to use.

Click here for SpotBot® Extreme Microarrayers.

February 26, 2013
microarray-slides
Arrayit Corporation is a leading manufacturer and developer of premium specialty glass products for the microarray industry, and the life sciences and diagnostics marketplaces. Our unique "start with the sand" manufacturing process begins by dictating proprietary silicon dioxide compositions direct to the foundry. Liquified glasses are cooled into premium glass sheets, polished to atomic smoothness, cut to precision dimensions and treated with premium chemistries to allow the attachment of DNA, proteins and many other biomolecules. Attention to all manufacturing aspects produces specialty and custom glass that offer greater transparency, lower background, higher signal-to-noise, and greater lot consistency that competing manufacturers.

Click here for premium Arrayit glass products.

February 7, 2013
inflammatory-response
Arrayit has developed an advanced focused DNA microarray to allow gene expression analysis of the human inflammatory response and autoimmunity signaling pathways. Microarrays contain printed long-mer oligonucleotides representing 375 inflammatory response and autoimmunity genes including chemokine ligands, chemokine receptors, CD molecules, colony stimulating factors, coagulation factors, fibroblast growth factors, histone deacetylases, interferons, interleukins, interleukin receptors, leukemia inhibitory factors, lymphocyte antigens, calcium binding proteins, serpin peptidase inhibitors, toll-like receptors, tumor necrosis factors, vascular endothelial growth factors, and many others. Oligonucleotides are designed to detect the maximum number of cellular transcripts per gene, which increases the detection of rare cellular transcripts. Arrayit Inflammatory Response and Autoimmunity Microarrays utilize the standard glass substrate slide microarray format (25 x 76 mm) to ensure compatibility with >100,000 microarray fluorescence scanners. Researchers and clinicians can enhance insight into acute and chronic inflammation, Addison's disease, allergies, apoptosis, bacterial and viral pathogens, celiac disease, Churg-Strauss syndrome, diabetes, Graves' disease, Hashimoto's thyroiditis, idiopathic thrombocytopenic purpura, immune system, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus and Sjögren's syndrome.

Click here for Inflammatory Response and Autoimmunity Microarrays.

January 18, 2013
Parkinsons-Disease
Arrayit Corporation has utilized genomic expression profiling and advanced bioinformatics to decipher the molecular basis of Parkinson's Disease (PD). In a collaboration with The Parkinson's Institute (Sunnyvale, CA), we compared messenger RNA levels in PD patients and controls, and identified a subset of 30 cellular genes dramatically up- and down-regulated in a PD-specific manner. Bioinformatic analysis of the gene signature revealed that Parkinson's Disease is caused by a perturbation of the protein folding and unfolding pathway, consistent with the formation of Lewy Body protein aggregates in patients with advanced PD. Based on the 30 gene markers, we developed the PDx™ molecular screening test that shows 100% sensitivity and 100% specificity in identifying Parkinson's Disease. PDx™ correctly detects the PD expression signature in symptomatic patients as well as in pre-symptomatic individuals 25 years before the appearance of symptoms, providing an extensive window for therapeutic intervention in pre-symptomatic patients. We are currently seeking a pharma or diagnostics strategic partner to advance PDx™ to a 510(k) FDA submission.

Click here for Parkinson's Disease Test PDx™.

December 26, 2012
microarray-cleanrooms
Arrayit microarray cleanroom technology enhances all aspects of microarray experimentation including sample preparation, manufacturing, processing, scanning, and data analysis and mining. Our cleanroom suits, gloves, sticky mats, face shields, and other products improve data quality by ensuring the integrity of single cell amplification, PCR for gene expression and genotyping, RNA and protein microarrays, and other exacting applications including molecular diagnostics that benefit from pristine, contaminant-free work environments. Arrayit class 100 cleanrooms are custom-built to customer specifications and fully optimized for microarray analysis. Arrayit cleanroom products work in harmony with our ergonomic microarray cleanrooms to improve the performance of microarrayers, scanners, plate stackers, liquid handlers and other automation equipment. Based on more than a decade of continuous R&D, Arrayit microarray cleanroom technology is essential and affordable equipment for basic research, life sciences, pharmaceutical and diagnostics laboratories.

Click here for microarray cleanroom products.
Click here for class 100 cleanrooms.

December 4, 2012
therapeutic-proteins
Arrayit Therapeutic Protein Discovery and Validation Services enable rapid and precise analysis of therapeutic protein function. Customers provide messenger RNA (mRNA) samples from control cells and cells treated with a novel or known therapeutic protein, and Arrayit performs "deep" transcription profiling using the company's H25K Whole Human Genome Chips, which report to more human transcripts than any gene expression product on the market. H25K analysis generates a list of therapeutic protein-elicited activated and repressed genes and assembles millions of gene expression data points into a best-fit biological pathway using Arrayit proprietary Genome Pathway Builder™ software. Customers use the information from in vitro cell culture and in vivo animal studies to speed discovery of the next blockbuster therapeutic protein drug. Monoclonal antibodies, GCSF, FSH, blood clotting factors, interferon, insulin, EPO and other expressed and secreted proteins representing a growing $100B U.S. market can be tested using Arrayit Services.

Click here for therapeutic protein profiling.

November 9, 2012
NanoPrint microarrayer
Arrayit NanoPrint™ Enterprise Level Microarrayers are the market's leading instruments for professional microarray manufacturing. NanoPrint™ LM60 and LM210 instruments print 10,000 samples onto 60 and 210 glass substrate slides, respectively, in 8 hours and 21 hours at 0.5 µm positional resolution for unparalled precision and throughput in advanced research, R&D, production and diagnostics applications. Installed in major technology centers worldwide and featured in hundreds of scientific publications, NanoPrint™ microarrayers empower DNA, protein, peptide, antibody, carbohydrate, reverse phase, and whole cell microarray experimentation using 48 patented contact printing pins controlled by near frictionless linear drive technology and WARP1 controllers. Environmental control, plate stackers, HEPA filtration, ultrasonic pin cleaning, plate cooling and other standard features and options deliver 99.99%+ printing efficiency consistently under the most demanding conditions, with custom systems available for proprietary printing applications.

Click here for NanoPrint™ Enterprise Microarrayers.

October 12, 2012
SpotBot microarrayers
Arrayit SpotBot® 3 Personal Microarrayers are the market's leading instruments for desktop microarray printing. SpotBot® prints 384 samples on 14 glass substrate slides in 2 hours for unparalled convenience in prototyping, research, R&D and diagnostics. Installed in more than 375 laboratories worldwide and featured in hundreds of scientific publications, SpotBot® microarrayers empower DNA, protein, peptide, antibody, carbohydrate, reverse phase, and whole cell microarray experimentation using 4 patented contact printing pins. Customers enjoy humidity control, cooled and heated platens, sonic pin cleaning, advanced vision system and other convenient options to personalize each instrument. Compact, affordable and easy to use, SpotBot® 3 sets the standard for automated desktop microarray manufacturing.

Click here for SpotBot® 3 Personal Microarrayers.

September 18, 2012
microarray printing pin
Arrayit microarray printing pins drive the market's most widely used microarray manufacturing technology, with >100,000,000 microarrays manufactured since we introduced our patented contact printing technology in 1997. Arrayit microarray pins empower custom DNA, protein, lysate, small molecule, lipid, carbohydrate and whole cell microarrays containing 1-360,000 printed elements. Pins and printheads have been refined recently to provide superior printing efficiency, greater row and column regularity and improved printed spot precision. Customers can choose from more than 100 pin styles to print low- and medium-density microarrays containing up to 360K spots of superior quality. Arrayit empowers new and continuing customers with the tools required to upgrade their existing manufacturing capabilties. Explore new frontiers in biomedicine with ex situ microarrays!

Click here for microarray printing pins.

August 28, 2012
premium-glass
Arrayit is a leading provider of premium quality glass substrate slides for scientific applications including DNA microarrays, microfluidics, and a wide range of life sciences and diagnostic applications. We provide our proprietary borosilicate compositions to the foundry to obtain the finest quality glass wafers available. Wafers are polished to atomic smoothness, cut to precision dimensions and ground to obtain polished edges and corner chamfers for optimal fluorescence performance and unambiguous side orientation. Arrayit series 3 glass is available with many different surface chemistries including epoxy, aldehyde, amine, methacrylate as well as ultraclean silicon dioxide for the addition of customer chemistries. Custom size dimensions, hydrophobic masks, laser etching and many other treatments are available at affordable prices for custom assays. Class 100 cleanroom manufacturing ensures the finest quality control and quality assurance of our premium glass products.

Click here for premium series 3 glass substrate slides.

August 10, 2012
Arrayit-Platform

Arrayit welcomes Roche NimbleGen customers (http://bit.ly/NATNU3) to the Arrayit Microarray Platform. Our extensive line of high-density microarray products and services include complete cleanroom and laboratory packages featuring high-density linear drive microarrayers, market-leading 0.5 µm high-resolution microarray scanners, custom BioBlue bioinformatics workstations, human genome microarrays with 250,000 transcript detectivity, high-performance hybridization stations and hundreds of other Roche NimbleGen compliant tools, kits and reagents. We have provided our atomically smooth, proprietary polished glass substrate slides and high-speed microarray centrifuges as business-to-business products to Roche NimbleGen for nearly a decade. Please contact our technical support experts for assistance designing your new microarray platform. We look forward to facilitating a smooth customer transition from Roche NimbleGen to Arrayit.

Click here for high-density scanners.

July 23, 2012
Arrayit-2012 Catalog
Arrayit has a 15-year track record of success as a microarray technology market leader. Our new summer 2012 catalogs, including the impressive high definition (HD) version, showcase an impressive collection of 1,200 leading-edge products and services including contract microarray manufacturing, gene expression and genotyping services, VIP microarray cleanroom platforms, clinical research products, microarrayers, scanners, hybridization stations, microarray printheads and printing pins, environmental enclosures, high-speed computers, human genome chips, focused DNA and protein microarrays, labeling and purification kits, cleanroom products, hybridization and wash buffers, printing and blocking solutions, glass substrate slides, custom glass substrates for next generation sequencing, blood collection and separation cards, microarray books and many others for research, life sciences, diagnostics, pharmaceuticals, and health care. Download our summer 2012 catalogs for the latest information on Arrayit - the microarray company.

Click here for Summer 2012 Microarray Catalogs.

July 2, 2012
Personal microarray spotter
Arrayit is the market leader in personal desktop microarray spotters. SpotBot® 3 Personal and SpotBot® Extreme systems enable compact and affordable microarray manufacturing with space-saving instruments that are ideal for basic research, R&D, diagnostics, pharmaceutical studies and many other applications involving genotyping, gene expression, serum profiling, reverse phase microarrays and CGH. With more than 380 personal microarrayers installed worldwide and a 15-year track record of success in microarray printing, Arrayit microarray technology offers speed, precision and ease-of-use that facilitate new discoveries more efficiently than other platforms. Our personal microarray spotters include patented contact printing technology, printing pins and professional series printhead, personal computer, LED flat panel display, keyboard, mouse and an installation time of less than one hour. Each system includes complete technical support, 24-hour on-line software assistance, and a supporting line of 1,200 Arrayit products and services to provide all of the tools, kits and reagents required for the most demandiing microarray experiments.

Click here for Personal Microarray Spotters.

July 2, 2012
microarray-scanning-service

Arrayit offers premium microarray scanning and data analysis services for microarrays manufactured by Arrayit, Agilent, Roche NimbleGen and other suppliers compliant with the standard glass substrate slide format. Scanning and data analysis are performed in our class 100 cleanrooms using sophisticated high-speed Arrayit InnoScan® Microarray Laser Scanners providing 3.0 µm scanning resolution at optimized gain and laser settings for DNA, RNA, protein, peptide, and many other types of printed microarrays. Autoloaders enable high throughput barcode reading and microarray scanning of up to 24 microarrays per run and thousands of microarrays per day providing premium quality data for academic labs, hospitals, government agencies, foundations, biotechs, pharmas and diagnostics companies. Data are uploaded to our confidential servers to allow customer data access in real time.

Click here for Microarray Scanning and Data Analysis Services.

May 15, 2012
rare disease
Arrayit offers the market's first service dedicated to deciphering rare human diseases. Rare (orphan) diseases are conditions presenting in a small percentage of the population, typically from 1 in 1,000-200,000 persons. More than 3,100 rare diseases have been identified but in many cases the molecular details are poorly understood. We deploy our patented and proprietary microarray platform on a genomic scale to elucidate the molecular basis of rare diseases quickly and efficiently. Control and test samples of mRNA are compared to produce a gene expression signature for each disease, and the gene expression data are examined computationally to produce a "best-fit" biological pathway. The sensitivity and specificity of our microarray platform enables a deeper examination of the transcriptome than competing platforms and a more complete understanding of rare/orphan diseases. Genotyping and proteomic analyses are also available to confirm and extend the mRNA results.

Click here for Rare Human Disease Analysis.

May 2, 2012
streptavidin microarray slides
Arrayit Corporation offers the market's finest streptavidin microarray substrate slides for binding reactions with biotinylated molecules. SuperStreptavidin utilizes our premium atomically polished glass for a superior substrate that includes polished edges and a corner chamfer for unambiguous orientation in the laboratory. The glass surface is activated with a high coupling efficiency silane reagent that attaches the streptavidin proteins in a covalent manner across the entire 25 x 76 mm surface at 1.1 x 10^10 streptavidin proteins per mm^2. Superstreptavidin can be used to manufacture high density microarrays containing oligonucleotides, peptides, proteins, antigens, antibodies, carbohydrates, small molecules, cell extracts and many other biotin samples. Class 100 cleanroom manufacturing and packaging ensures optimal quality and performance of this popular product line.

Click here for SuperStreptavidin Microarray Substrate Slides.

April 17, 2012
blood cards
Arrayit has developed an advanced blood card technology that collects and fractionates whole blood into red blood cells, white blood cells and serum components quickly, easily and affordably. Our unique linear separation chromotography collects 5 droplets of whole blood and separates and dries the whole blood components in 10 minutes to ensure sample integrity. Arrayit Blood Cards can be used to fractionate, ship, obtain and store samples for a variety of research, veterinary and in vitro diagnostic applications including protein-based allergy testing and cancer diagnostics. Blood Card fractionation removes contaminants that elevate background in protein microarrays and other assays. Blood Cards can be used to isolate DNA and mRNA for genotyping and expression profiling applications. Barcode and unique patient identifier permit unambiguous sample tracking and data assignment. QR code allows website access using mobile devices, and small "business card" size of 2 x 3.5" (5 x 8.9 cm) conserves space at testing facilities.

Click here for Blood Cards and Sampling Kits.

April 5, 2012
GMOs
Genetically Modified Organisms (GMOs), plants and animals harboring genes modified through genetic engineering, are seeing greater usage in commercial agriculture where a majority of crops including soybean, corn and cotton have been modified genetically to confer resistance to herbicides and viral and insect pathogens. GMO crops offer improved nutritional content, better shelf life, and more robust growth in difficult environmental conditions such as climates prone to drought and increased salinity. Certain plants have been engineered to metabolize chemicals and other environmental pollutants as organic solutions to bioremediation. GMO animals including mice, rats, sheep, goats and dairy cows are seeing greater utilization in medical research as well as in the production of pharmaceutical drugs and livestock products with better nutritional quality. Mosquitos have been engineered to carry genes that combat malaria as a deployable defense against this global infectious disease. The increasingly widespread use of GMOs necessitates the availability of testing technologies capable of identifying GMOs rapidly, accurately and affordably and tools capable of quantitatively understanding the genomic and proteomic consequences produced by genetically altering these organisms. It is also increasingly important to be able to differentiate GMO and non-GMO unambiguously to address potential safety concerns, ecological issues, and consumption rates of these products in markets worldwide.

Arrayit offers advanced microarray platforms such as class 100 cleanrooms built to your specifications, as well as microarrayers, scanners, DNA and protein microarrays, and all of the tools, kits and reagents needed to analyze genetically modified organisms quickly, easily and in an affordable manner. We also offer detailed protocols and the technical know-how required to develop methods for isolating, amplifying, labeling and screening DNA, mRNA and protein samples from seeds, plant materials, insect and animal preparations and other GMO and non-GMO materials. Microarray technology is the ideal GMO platform owing to its miniaturization, parallelism and automation.

Click on these links for GMO platforms, microarrayers and scanners.

March 12, 2012
microarray-scan
Arrayit announces the availability of its new SpotLight™ 2 Microarray Fluorescence Scanners, a leading edge line of highly affordable two-color scanners that build on the seven-year time tested tradition of the SpotLight™ brand name. SpotLight™ 2 offers greater detectivity, faster scan speeds, improved image quality and a more compact instrument footprint than the original SpotLight™ scanners. SL2 uses a high-performance digital detector, cool monochromatic excitation light sources and precision motion control to capture high quality 16-bit TIFF scanned images at 10 µm resolution of any glass substrate slide (1 x 25 x 76 mm) containing cyanine 3 (532 nm) and cyanine 5 (635 nm) fluorescent dyes. SL2 "Blue" is a new two-color SpotLight™ 2 scanner that detects fluorescein isothiocyanate (FITC) 488 nm "blue" and 635 nm cyanine 5 fluorescent dyes for users detecting FITC-labeled oligonucleotides, antibodies, antigens, proteins, peptides and other probe types in a two color format. SpotLight™ 2 systems include a BioBlue High-Speed Personal Computer, 23" LED flat panel display, keyboard, mouse, mouse pad and accessories for the ultimate personal microarray scanner experience and customer configuration times of less than one hour. Priced at under $32K USD, SpotLight™ 2 Microarray Fluorescence Scanners are the best-performing and most affordable fluorescent scanners on the market. SL2 is highly recommended for academic, core, government and corporate research laboratories and diagnostics centers.

Click here for SpotLight™ 2 Microarray Scanners.

February 22, 2012
linear drive microarrayers
Arrayit Corporation provides the market's finest and most widely used linear drive microarrayers for advanced microarray manufacturing. Linear drive systems utilize electricity and magnetism for highly repeatable, nearly frictionless motion control of the entire microarray printing process. Linear drives and encoders ensure ±0.5 µm micron positional resolution for extraordinary printing quality and expedited data analysis and mining. Linear drive LM60 and LM210 Enterprise Level Microarrayers, with respective 60 and 210 glass substrate slide capacities, employ our patented contact printing technology used in 3,950 institutions worldwide. Megasonic pin cleaning and environmental control ensure DNA and protein microarray printing efficiencies of >99.99%. A wide assortment of interchangeable pin styles permit 37.5-600 µm spot diameters and hundreds to thousands of printed spots per pin loading. Microplate hotels are available for completely automated manufacturing of 360,000 spot microarrays for high-throughput biology based on your unique, confidential and proprietary content. Arrayit's linear drive microarrayers are class 100 cleanroom compatible for customers wishing to achieve professional quality microarrays at an affordable price with our nearly maintenance-free instruments. A complete line of >1,000 highly optimized tools, kits, reagents and consummables provides seamless workflow integration.

Click here for Linear Drive Microarrayers.

February 9, 2012
drug metabolism
Drug metabolism is a cornerstone of modern research and the pharmaceutical and healthcare industries because this metabolic process determines the rate of uptake, conversion of prodrugs into active drugs, and the speed by which active drug compounds are modified into less active metabolites in the human body. Drug metabolism is carried out primarily by enzymes located within the smooth endoplasmic reticulum of liver cells, though all cells have the biochemical capacity to metabolize drugs to a certain extent. Phase I metabolic reactions typically involve cytochrome P450 enzymes, resulting in the conversion of drugs from lipophilic to more hydrophilic compounds via oxidation and reduction reactions. Phase II reactions often involve cellular transferases, which add substituents such as methyl, sulfur, amino acid and other groups to aid in drug detoxification by facilitating excretion. Because drug metabolism is carried out by a large family of gene products, the ability to quantitatively measure drug metabolism gene expression is central to understanding this xenobiotic process.

Arrayit drug metabolism microarrays (Cat. DMPM) containing 89 oligonucleotide gene targets to alcohol dehydrogenases, arachidonate lipoxygenases, cytochrome P450 genes, glutathione peroxidases, glutathione S-transferases, hydroxysteroid dehydrogenases, paraoxonases, steroid reductases and other gene families allow researchers to quantify "drugmet" gene expression rapidly and affordably. Drug metabolism microarrays permit quantitative expression analysis of all 89 genes plus controls simultaneously and accurately using fluorescence labeling, hybridization, scanning and digital data analysis. Two color detection with cyanine 3 and cyanine 5 allows comparative expression analysis of control and test samples to pinpoint genes involved the metabolism of commercial drugs, chemotherapeutic agents, lead compounds and other chemical substances.

Click here for Drug Metabolism Microarrays.

January 21, 2012
SpotBot® microarrayers
Arrayit SpotBot® Microarrayers empower powerful science on the benchtop. The world's best selling microarray printers are available as SpotBot® Personal, SpotBot® Extreme and SpotBot® Titan instruments with respective 14, 28 and 144 substrate slide capacities. The entire SpotBot® line is equipped with our patented contact printing technology, which is installed in more than 3,900 laboratories worldwide and allows researchers to uniquely create microarrays of virtually any biological or chemical sample type including DNAs, proteins, carbohydrates, small molecules, peptides, patient amplicons, RNAs, antibodies, lipids, drugs, human sera, cell extracts and whole cells. SpotBot® printheads accomodate hundreds of fully interchangeable printing pin styles including solid tips, 0.25-1.25 µl sample channels, standard and extended collars, 0.0015-0.015" tip widths, and stainless steel or professional series RM101 proprietary alloy composition. Cooled platens, humidity control and megasonic pin cleaning options facilitate the most demanding applications including reverse phase and other protein microarray applications. An intuitive graphical interface, BioBlue Mini Computer and 23" LED flat panel display facilitate the creation of custom printing routines within minutes. Our complete line of reagents, solutions, buffers, kits and glass substrate slides compliment the full gamut of microarray applications.

SpotBot® microarrayer installation is fast and easy. We offer complete technical support with the sale of each instrument including assistance with the selection of consummables and assay development. Building on an 11-year track record of success and with 370 instruments sold worldwide, Arrayit is the market leader in automated microarray manufacturing.

For Arrayit microarrayers, click here.

January 4, 2012
microarray products
Arrayit microarray products enable researchers to explore the amazing natural world of plants, animals, fishes and other organisms with unprecedented speed, precision and affordability. Use our "tool kit" of >1,000 sophisticated platforms, microarrayers, fluorescence scanners, hybridization stations, pre-printed microarrays, glass substrate slides, labeling kits and biological reagents to develop new assays, discover novel gene and protein functions, elucidate signalling pathways, identify important SNPs and create a deeper and richer understanding of the biosphere.

Click here for microarray products.

December 15, 2011
microarray technology
Arrayit microarray technology combines miniaturization, parallelism and automation to enhance scientific projects in basic research, life sciences, clinical medicine and healthcare. Miniaturization with micron-sized printed microarray spots allows entire genomes and proteomes to be analyzed in a single test. Miniaturization improves affordability compared to traditional assays and increases reaction kinetics to speed analysis. Millions of patient DNA samples can be analyzed quickly and economically using Arrayit VIP microarrays. Parallelism enables genes, proteins, antibodies, patient samples and other printed biochemical materials to be tested simultaneously using a single probe mixture, which significantly improves accuracy and precision compared to serial methods. Automation leverages high-speed microarray printers, fluorescence scanners, plate stackers, hybridization stations, and other automation equipment to accelerate discovery and improve precision, allowing scientists and doctors to publish faster than their colleagues and develop new products more quickly than the competition. Arrayit microarray technology, based on the latest advances in Silicon Valley, is robust, affordable and easy to implement.

Click here for the Arrayit microarray store.

November 28, 2011
microarray laboratory
Arrayit Microarray Laboratories provide a one-stop shop for customers wishing to expand, update or configure a new microarray laboratory. We offer the market's finest cleanrooms, microarrayers, scanners, ozone-free boxes, liquid handling robots, hybridization stations, consumables and software for research, manufacturing, and molecular diagnostics. Arrayit class 100 cleanrooms are free-standing, custom-designed class 100 facilities featuring rugged construction, advanced filtration, cool LED lighting, and a 10-year performance guarantee. NanoPrint™ enterprise microarrayers offer sub-micron positional resolution for near frictionless microarray printing. SpotBot® personal microarrayers are award-winning desktop instruments for prototyping and targeted applications. Arrayit InnoScan® microarray scanners feature 0.5 micron scanning resolution and rotary motion control. Ozone-free boxes are available in several convenient sizes to eliminate ozone from experiments and surfaces that utilize ozone-sensitive fluorophores. Oasis™ liquid handling robots provide dependable low-volume automated pipetting for PCR purification and sample preparation. TrayMix™ hybridization stations use chaotic advection mixing to speed reaction kinetics by 10-fold to acheive optimal hybridization and protein binding specificity and sensitivity. A complete line of preprinted microarrays, substrate slides, and buffers for printing, blocking, hybridization, and washing have been developed to work in harmony with each laboratory component. Mapix® controller and quantification software provides high-speed data quantification complete with extensive statistics for downstream data analysis.

Arrayit microarray laboratories are configured to meet every budget and project size, from the smallest research laboratories to full-scale commercial microarray manufacturing and screening operations. Gene expression, genotyping and a wide range of protein assays can be designed to accelerate cutting-edge life science projects including human disease analysis, drug safety screening, oncology, food allergy testing, and basic science focused on mice, fruit flies, nematodes, higher plants, yeast, bacteria, viruses and many other organisms. A microarray laboratory can be used to miniaturize your current assays for greater throughput and accuracy and considerable cost savings.

For microarray laboratory products, click here.

November 2, 2011
HotBot Microarrayers
Arrayit SpotBot® "HotBot" Personal Microarrayers enable microarray printing at elevated temperatures for the manufacture and analysis of enzyme protein microarrays and whole cell microarrays of bacteria, yeast, mammalian cells and other cells and samples. HotBots build on the 10-year success record of the SpotBot® product line, with more than 360 instruments in the field and hundreds of highly cited scientific publications. Advanced micro-robotics and microstepping in an open loop allow affordable 10 µm positional resolution in a compact desktop instrument that is intuitive, easy to use and fully portable. HotBots utilize Arrayit's patented contact printing technology for a wide range of printed spot diameters and sample loading volumes. Choose from among dozens of interchangeable pin tip configurations to achieve 37.5-500 µm spot size and >1,000 printed spots from a 0.2 µl sample uptake. Peltier-driven liquid heating technology is used to achieve ambient-45°C heating with ±0.1°C accuracy. HotBot systems include megasonic pin cleaning and Vision System as purchase options, all of the components and consummables required for immediate experimentation, and a BioBlue Bioinformatics Mini Computer with pre-loaded software, 20" LED flat panel display, keyboard, mouse, mouse pad and cables to complete each package.

HotBot Microarrayers can be used to miniaturize macroscopic assays for the selection of temperature sensitive bacterial and yeast mutants, high-density screening of pharmaceutical compounds, massively parallelized analysis of enzymatic catalysis and protein structure studies, and many other life science applications benefitting from the combination of microarray analysis and elevated temperature control. System set-up time is approximately 1 hour and custom software is available for specialized applications.

Click here for our new "HotBot" Microarrayers.

October 20, 2011
infrared scanners
Arrayit InnoScan® Infrared Microarray Scanners offer the market's finest and most affordable solution to near infrared (NIR) microarray scanning. Our 710IR and 710IRAL infrared microarray scanners feature 3 µm resolution, simultaneous and sequential scanning at 632 nm (cyanine 5) and 785 nm (infrared) wavelengths, 3.5 minute whole substrate scan time (10 µm), proprietary rotory cam motion control, laser diode excitation, high detectivity photomultiplier tube (PMT) detection, adjustable low and high laser settings, adjustable 0-100% PMT gain, 100-240 VAC power, real-time autofocusing, 300 µm manual focus in 1 µm increments, 16-bit tagged image file format (TIFF) data, standard 25 x 76 mm substrate slide format, 22 x 74 mm fully adjustable scan area, 10-35 lines per sec scan speed, 1-24 slide autoloader (Cat. 710IRAL), MAPIX® controller and quantification software, BioBlue Bioinformatics Computer with 64-bit operating system and 6 GB RAM, 23" LED flat panel display, keyboard, mouse, mouse pad and cables.

Many biological and chemical substances absorb strongly in the visible wavelength range (380-750 nm), which can result in elevated background and reduced detectivity and signal-to-noise ratios in microarray assays based on standard cyanine 3 and cyanine 5 dyes. Microarray labeleling and detection schemes utilizing 785 nm near infrared dyes can reduce background and improve detectivity by up to 1,000 fold in specific applications including protein microarrays printed on nitrocellulose and other surfaces. Arrayit InnoScan® 710IR and 710IRAL infrared scanners provide the performance of two-color near infrared and visible scanning in portable, desktop instruments that are robust, reliable and fun to use.

New! Click here for Infrared Microarray Scanners.

October 4, 2011
bioinformatics computer
Arrayit BioBlue Bioinformatics Computers are designed for high-end instrument control and computing applications including high resolution microarray scanning, next generation sequencing, and the bioinformatic analysis of microarray data for gene expression, protein expression, genotyping, genomics, proteomics and diagnostics. Arrayit designs and builds BioBlue and BioBlue Mini Computers using the finest components and specifications available including Intel i7-2600 technology, H67 chipsets, Genuine Windows® 7 Professional with the latest Microsoft updates, 1 TB Serial ATA 3 Gb/s Hard Drives (7200 RPM) w/32 MB cache, 8 GB DDR3 RAM, 10/100/Gigabit ethernet, Integrated 8.1 Channel Audio, IEEE 1394 Firewire interfaces, front access 2 x USB 2.0, 2 x HD Audio, 1 x Firewire, CD/DVD burner (DVD+/-RW), PCI-Express compatible video card, ultra-light LED flat panel displays, keyboard, optical mouse and mouse pad. Enjoy high-speed computing free of the "bloatware" found on mainstream commercial computing systems. BioBlue computers are fast, robust, compact, light weight and include a 1 year parts and labor warranty. With dozens of BioBlue Computers installed worldwide, Arrayit is setting a new standard for personal life sciences computing.

Click here for BioBlue Bioinformatics Computers.

September 19, 2011
microarray cleanroom
Arrayit VIP Microarray Cleanroom Packages provide the ultimate working environments for microarray printing, life sciences experimentation, and diagnostics, featuring Platinum, Gold, Silver and Bronze platforms with throughputs from 50,000-5,000,000 patient samples annually. Arrayit cleanrooms are constructed using rugged proprietary non-outgassing and ultra-low particle count materials to maximize their utility for biological applications. Cleanrooms include main laboratory modules, changing rooms, ULPA filtration, air conditioning, ventilation, filtered water, 110 and 220-volt electricity, and premium LED lighting for cool illumination, enhanced optics and incomparable appearance. Microarrayers, scanners, liquid handlers, PCR machines, spectrophotometers, autoloaders and other instruments required for DNA and protein microarray manufacturing and testing are included. Platforms also include high-speed BioBlue computers, flat panel displays and complete software for instrument control, sample tracking and data analysis and mining, as well as a full line of Arrayit consummables for sample amplification, purification, microarray printing, hybridization, and VIP microarray screening. Cleanroom apparel, wipes, nitrile gloves, and sticky mats allow same-day operation and use. Licenses to Arrayit's worldwide genotyping patents offer premium IP protection to all customers.

Arrayit microarray cleanrooms are modular, free-standing class 100 facilities that integrate easily into existing building space and are custom-configured to maximize ergonomics and usability. Based on more than a decade of R&D, all of our cleanrooms include a comprehensive 10-year performance guarantee. These facilities improve manufacturing and assay quality, reduce biological and enzymatic contamination, and offer premium appearance and performance for researchers and clinicians worldwide.

Click here for VIP Microarray Cleanroom Packages.

September 15, 2011
NHS-ester
Arrayit NHS-Ester Microarray Substrate Slides provide the market's finest surfaces for whole cell, protein, carbohydrate and small molecule microarray printing and experimentation. Based on highly advanced tri-functional organic chemistry and semi-conductor quality class 100 cleanroom manufacturing, Arrayit's new SuperNHS Slides offer high loading capacity and extremely low background when ultimate signal-to-noise ratios are essential. Our atomically smooth glass substrate slides are reacted with the first portion of the tri-functional polymer to produce a highly durable coating resistant to the broad range of temperatures and reactions conditions used in microarray assays. The second portion of the polymer contains highly reactive n-hydroxysuccinimide (NHS) ester groups, which form avid covalent bonds with primary amines and other nucleophiles present on the surface of whole cells, proteins, carbohydrates, small molecules and other printed sample molecules. The third polymer moiety contains a hydrophilic functionality that shields the glass surface from non-specific binding to produce remarkably low background.

SuperNHS slides are manufactured with an innovative corner chamfer for unambiguous side- and end-orientation during the experimental process, a polished edge for high-end appearance and enhanced user safety, and optional barcoding for easy sample tracking. The 25 x 76 x 1 mm glass dimensions are supported by Arrayit's entire line of industry-leading instrumentation including microarrayers, scanners, hybridization stations, quantification and analysis software, and other tools, kits and reagents. This two-dimensional, highly transparent surface chemistry is highly recommended for whole cell assays, proteomics, glycomics, high-throughput drug screening, and all other applications requiring a premium microarray surface. SuperNHS leverages thousands of peer-reviewed scientific publications, a 14 year track record of product quality, affordability, and versatility, incomparable technical and assay support, and a network of knowledgeable distributors for our academic, biotech, government, pharamaceutical and diagnostics customers.

Click here for SuperNHS Microarray Substrate Slides.

September 6, 2011
industrial microarrayers
Arrayit LM60 and LM210 NanoPrint™ Industrial Microarrayers are engineered to meet the most demanding requirements of the world's leading microarray manufacturing centers including core facilities, academic and government laboratories, hospitals, pharmaceutical and biotechnology companies, and other facilities dedicated to industrial-strength microarray manufacturing. Arrayit LM60 and LM210 microarrayers utilize 48 patented microarray printing pins to print with high speed and high precision onto 60 and 210 glass substrate slides, respectively. NanoPrint™ employs proprietary WARP1 controllers and advanced linear drive motion control to deliver sub-micron positional resolution in three dimensions in a manner essentially free of friction, noise and thermal emission. All NanoPrint™ systems include a Professional Series Printhead, HEPA filtration, humidity control, megasonic pin cleaning, high-speed computer, and flat panel display as standard features.

NanoPrint™ customers use an intuitive and highly sophisticated design wizard to specify the full gamut of printing parameters including the pin tip size, and the number of pins, microplates, substrate slides, technical replicates and replicate microarrays. Automatic method validation, sample and printing views and simulation mode confirm the validity of printing parameters prior to running the program. NanoPrint™ microarrayers deposit high-precision biochemical content onto the glass substrates including oligonucleotides, PCR amplicons, cDNAs, BACs, synthetic genes and chromosomes, antibodies, peptides, antigens, recombinant proteins, serum and plasma samples, small molecules, carbohydrates, mimitopes, nanoparticles, whole cells, and virtually any other sample type capable of capillary loading and absorptive printing. Microplate cooling, anti-vibration tables, environmentally-controlled 42- and 189-microplate stackers, and custom worktables for microplate and proprietary printing substrates are among the advanced options afforded to NanoPrint™ customers. Since 1997, Arrayit has empowered the microarray industry to manufacture an estimated 100 million microarrays, a time-tested tradition of excellence and performance embodied in the entire NanoPrint™ product line.

Click here for NanoPrint LM60 and LM210 Industrial Microarrayers.

 

 

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